Abstract #2057

Clinical correlations of DTI and volumetric metrics in people with multiple sclerosis

Abdulaziz Alshehri^1,2, Oun Al-iedani^1,2, Jameen Arm^1,2, Neda Gholizadeh¹, Thibo Billiet³, Rodney Lea², Jeannette Lechner-Scott^1,2,4, and Saadallah Ramadan^1,2

¹University of Newcastle, Newcastle, Australia, ²Hunter Medical Research Institute, Newcastle, Australia, ³Icometrix, Leuven, Australia, ⁴John Hunter Hospital, Newcastle, Australia

This study is to evaluate DTI parameters in RRMS patients with age and sex-matched HCs, and to correlate these DTI metrics values in total-brain white matter (TBWM) and white matter lesion (WML) in comparison to white matter-related volumetric measures with clinical symptoms showing the differentiation and significant P-values. DTI parameters showed a stronger correlation with clinical parameters than white matter-related volumetric measurements in RRMS. Importantly, more DTI parameters (16 metrics) with stronger clinical correlations were obtained than volume measurements (5 metrics).

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