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Abstract #2057

Clinical correlations of DTI and volumetric metrics in people with multiple sclerosis

Abdulaziz Alshehri1,2, Oun Al-iedani1,2, Jameen Arm1,2, Neda Gholizadeh1, Thibo Billiet3, Rodney Lea2, Jeannette Lechner-Scott1,2,4, and Saadallah Ramadan1,2
1University of Newcastle, Newcastle, Australia, 2Hunter Medical Research Institute, Newcastle, Australia, 3Icometrix, Leuven, Australia, 4John Hunter Hospital, Newcastle, Australia

This study is to evaluate DTI parameters in RRMS patients with age and sex-matched HCs, and to correlate these DTI metrics values in total-brain white matter (TBWM) and white matter lesion (WML) in comparison to white matter-related volumetric measures with clinical symptoms showing the differentiation and significant P-values. DTI parameters showed a stronger correlation with clinical parameters than white matter-related volumetric measurements in RRMS. Importantly, more DTI parameters (16 metrics) with stronger clinical correlations were obtained than volume measurements (5 metrics).

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