Abstract #2058

Microstructural Gray Matter Abnormalities in Progressive Supranuclear Palsy and Corticobasal Syndrome: Evaluation by Free-water Imaging

Koji Kamagata¹, Christina Andica¹, Kaito Takabayashi¹, Yuya Saito¹, Wataru Uchida^1,2, Shohei Fujita¹, Toshiaki Akashi¹, Akihiko Wada¹, Kouhei Kamiya³, Masaaki Hori³, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan, ³Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) are neurodegenerative disorders characterized by the deposition of the abnormal 4 microtubule-binding domain (4R) tau protein in specific brain regions. Voxel-based morphometry (VBM) has been widely used in CBS and PSD; however, the detection of pathological changes of these diseases is challenging in the early stages, including with VBM. In this study, we used free-water imaging (FWI) to evaluate gray matter (GM) microstructural changes in CBS and PSP. We determined that FWI could detect GM abnormalities, which likely reflected tau-related pathology in CBS and PSP patients more sensitively than VBM.

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