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Abstract #2058

Microstructural Gray Matter Abnormalities in Progressive Supranuclear Palsy and Corticobasal Syndrome: Evaluation by Free-water Imaging

Koji Kamagata1, Christina Andica1, Kaito Takabayashi1, Yuya Saito1, Wataru Uchida1,2, Shohei Fujita1, Toshiaki Akashi1, Akihiko Wada1, Kouhei Kamiya3, Masaaki Hori3, and Shigeki Aoki1
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan, 3Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) are neurodegenerative disorders characterized by the deposition of the abnormal 4 microtubule-binding domain (4R) tau protein in specific brain regions. Voxel-based morphometry (VBM) has been widely used in CBS and PSD; however, the detection of pathological changes of these diseases is challenging in the early stages, including with VBM. In this study, we used free-water imaging (FWI) to evaluate gray matter (GM) microstructural changes in CBS and PSP. We determined that FWI could detect GM abnormalities, which likely reflected tau-related pathology in CBS and PSP patients more sensitively than VBM.

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