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Abstract #2059

Can Diffusion Kurtosis Imaging and 3D-Arterial Spin Labeling perfusion imaging improve the diagnostic accuracy of Binswanger's Disease?

Xiaoyi He1,2, Weiqiang Dou3, Hansen Schie1, and Junying Wang1,2
1Department of Medical Imaging, Shandong Provincial Qianfishan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, China, 2Shandong First Medical University, Taian, China, 3GE Healthcare, MR Research China, Beijing, China

This study aimed to investigate whether the combined 3D-arterial spin labeling (3D-ASL) and diffusion kurtosis imaging (DKI) can distinguish Binswanger’s disease (BD) patients from healthy subjects. 35 BD patients and 33 age/gender-matched controls were scanned in DKI and ASL at 3T. Compared with healthy subjects, significant alterations were found in almost all DKI & ASL relevant parameters on the major lesions and partial non-lesion regions of BD. With these findings, we thus proved that the combined DKI and 3D-ASL can be effectively tools exploring pathophysiological mechanisms and performing robust diagnostic accuracy for BD patients.

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