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Abstract #2079

4-D Flow CMR Reveals Inefficient PA Flow Correlates with Afterload in Repaired Transposition of the Great Arteries.

Marc Delaney1, Vincent Cleveland2, Paige Mass2, Francesco Capuano3, Yue-Hin Loke4, and Laura Olivieri4
1Pediatrics, Children's National Hospital, Washington, DC, United States, 2Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States, 3Industrial Engineering, Universita di Napoli Federico II, Naples, Italy, 4Pediatric Cardiology, Children's National Hospital, Washington, DC, United States

Repair of D- transposition of great arteries (DTGA) involves pulmonary artery (PA) manipulation that alters shape and flow patterns. Many patients experience increased right ventricular afterload and the etiology remains unclear. We examined the contribution of PA flow separation to afterload in these patients using 4D flow CMR imaging of a mock circulatory system incorporating 3D-printed PA replicas. We found that 2 distinct markers of flow inefficiency correlated with afterload. These data emphasize the utility of 4D flow CMR in quantifying abnormal blood flow and identifying important early clinical predictors of complications in DTGA.

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