We compare pseudo-spiral undersampled whole-heart 4D flow MRI with CS reconstruction with a clinically used EPI readout in a cohort of healthy subjects and patients with valve regurgitation. Our results indicate that pseudo-spiral CS 4D flow MRI is at least as reliable as EPI-based 4D flow MRI in terms of inter-valve consistency of blood flow measurements and agreement with 2D MRI-based regurgitant volume measurement. Doubling the undersampling factor of the CS acquisition results in <10% deviation of the measurements compared to the original acquisition, suggesting that CS scan times may be shortened to expedite clinical implementation.
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