Abstract #2103

Longitudinal Change in Quantitative Magnetic Resonance Imaging Biomarkers in Pediatric Patients with Autoimmune Liver Disease

Neeraja Mahalingam¹, Andrew Trout^2,3,4, Deep Gandhi¹, Ruchi Singh^5,6, Alexander Miethke^5,6, and Jonathan Dillman^2,3,5

¹Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States, ⁴Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States, ⁵Center for Autoimmune Liver Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁶Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Changes over time in liver and spleen T1 relaxation and MR elastography (MRE) measurements in children with autoimmune liver disease (AILD) have not been extensively studied as markers of disease. Iron (T2*)-corrected T1 (cT1) mapping and MRE were performed in 67 pediatric/young adult patients at baseline, 12, and 24 months. One-way ANOVA (mixed model) tests identified no statically significant changes in liver cT1 and liver and spleen stiffness over time but near-significant trends were identified. Further studies with larger sample sizes are needed to expand upon these preliminary results and define the roles of cT1 and MRE in clinical practice.

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