In- and opposed-phase imaging has become integral in liver MR imaging due to its ability to identify intravoxel fat or iron, important ancillary features in lesion characterization, particularly during hepatocellular carcinoma surveillance. Potentially, these features can be assessed through images acquired from dynamic contrast-enhanced imaging, rather than separate sequence acquisitions, decreasing scan times. Two blinded radiologists retrospectively reviewed MR liver examinations comparing in- and opposed-phase 2D-GRE imaging to 3D-SPGR Dixon imaging for the assessment of intralesional fat or iron. We found that there is no difference in fat or iron detection performance between dedicated 2D-GRE and 3D-SPGR Dixon sequences.
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