Recently, a novel non-Gaussian DWI model, known as the fractional order calculus (FROC) model, was developed for biomedical applications. Until now, hardly has the FROC-DWI been applied in the hepatic imaging Thus, this study aimed to evaluate the value of FROC diffusion model in staging liver fibrosis. According to our results, the FROC-DWI-derived parameters (D, β, and μ) were significantly correlated with fibrosis stages, contributing positively to non-invasive assessment of liver fibrosis. The combination of FROC-DWI and conventional mono-exponential DWI held great potential in noninvasively staging liver fibrosis, superior to serum fibrosis biomarkers including APRI and FIB-4.
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