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Abstract #2124

Staging chronic hepatitis B related liver fibrosis with a fractional order calculus diffusion model

Ruofan Sheng1, Yunfei Zhang2, Mengsu Zeng1, and Yongming Dai2
1Zhongshan Hospital affiliated to Fudan University, Shanghai, China, 2Central Research Institute, United Imaging Healthcare, Shanghai, China

Recently, a novel non-Gaussian DWI model, known as the fractional order calculus (FROC) model, was developed for biomedical applications. Until now, hardly has the FROC-DWI been applied in the hepatic imaging Thus, this study aimed to evaluate the value of FROC diffusion model in staging liver fibrosis. According to our results, the FROC-DWI-derived parameters (D, β, and μ) were significantly correlated with fibrosis stages, contributing positively to non-invasive assessment of liver fibrosis. The combination of FROC-DWI and conventional mono-exponential DWI held great potential in noninvasively staging liver fibrosis, superior to serum fibrosis biomarkers including APRI and FIB-4.

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