Compressed sensing (CS) has been reported to accelerate acquisition time in morphological imaging without image quality loss. The impact of CS on diffusion weighted imaging (DWI) in liver MRI has not yet been investigated. Therefore, the aim of our study was to test whether CS-based reconstruction is useful in echo-planar imaging (EPI) DWI. In this intra-individual comparison, EPI-DWI with CS-based reconstruction (CS-DWI) received comparable image quality ratings as conventional EPI-DWI. However, in a direct head-to-head-comparison, we found that a small fraction of focal liver lesions was missed on CS-DWI without apparent reason.