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Abstract #2146

Regional Gray Matter Volume Associated with Exercise Dependence: A Voxel-Based Morphometry Study

Zhang Feifei1, Zhiyun Jia2, and Qiyong Gong2
1Sichuan University, Chengdu, China, 2Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China, ChengDu, China

The present study provides initial evidence indicating that a higher risk of EXD is linked with a smaller GMV in the right OFC, left sgCG, and left IPL in a sample of regular exercisers, which sheds light on the neuroanatomical basis of EXD. Furthermore, our study found that the right OFC mediates the relationship between stress and EXD, revealing a potential neuropsychological mechanism for how stress affects EXD. Our findings might facilitate the diagnosis of EXD and the target selection for the corresponding intervention (e.g., behavioral or brain intervention ) to help individuals reduce EXD and improve their quality of life.

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