Present neuroradiological studies demonstrated significant alterations in surface-based morphology in patients with essential tremor (ET) relative to healthy controls (HC). The current study was achieved by exploring the abnormal brain morphological features of patients with ET by using three-dimensional T1-weighted imaging, as well as the relationship between demographic/clinical variables and affected structural cortical features. We found that ET patients showed significant structural changes both in the motor and non-motor brain regions and some abnormities were correlated with the clinical scales. Further, abnormalities attributed to ET can also be affected by various demographic and clinical variables.
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