Abstract #2148

Volume-based brain morphometry and T1 mapping: comparison between MP2RAGE accelerated by parallel imaging and compressed sensing at 3 Tesla

Blanche Bapst^1,2, Aurélien Massire³, Tobias Kober^4,5,6, Gian Franco Piredda^4,5,6, Bénédicte Maréchal^4,5,6, and Pierre Brugières¹

¹Department of Neuroradiology, Henri Mondor Universitary Hospital, AP-HP, Créteil, France, ²Faculty of Medicine, Université Paris Est Créteil, Créteil, France, ³Siemens Healthcare SAS, Saint-Denis, France, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁶Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

MP2RAGE is 3D T₁-weighted MR sequence used for high GM/WM contrast imaging, enabling morphometry, brain segmentation and T₁ mapping. Despite these advantages, it suffers from long acquisition times, hindering broad clinical adoption. In this work, brain data obtained from 29 patients with various pathologies using the GRAPPAx3-accelerated reference (8:22 min) and a new compressed-sensing version (4:00 min) of the MP2RAGE were compared with respect to brain volumetry and T₁ mapping results. Very high agreement was observed between the two versions. These results pave the way for a broader use of CS-MP2RAGE, eventually enabling its clinical use.

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