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Abstract #2148

Volume-based brain morphometry and T1 mapping: comparison between MP2RAGE accelerated by parallel imaging and compressed sensing at 3 Tesla

Blanche Bapst1,2, Aurélien Massire3, Tobias Kober4,5,6, Gian Franco Piredda4,5,6, Bénédicte Maréchal4,5,6, and Pierre Brugières1
1Department of Neuroradiology, Henri Mondor Universitary Hospital, AP-HP, Créteil, France, 2Faculty of Medicine, Université Paris Est Créteil, Créteil, France, 3Siemens Healthcare SAS, Saint-Denis, France, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 6Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

MP2RAGE is 3D T1-weighted MR sequence used for high GM/WM contrast imaging, enabling morphometry, brain segmentation and T1 mapping. Despite these advantages, it suffers from long acquisition times, hindering broad clinical adoption. In this work, brain data obtained from 29 patients with various pathologies using the GRAPPAx3-accelerated reference (8:22 min) and a new compressed-sensing version (4:00 min) of the MP2RAGE were compared with respect to brain volumetry and T1 mapping results. Very high agreement was observed between the two versions. These results pave the way for a broader use of CS-MP2RAGE, eventually enabling its clinical use.

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