Abstract #2149

Comparison of cortical gray matter and subcortical gray matter using double diffusion encoding

Shimpei Kato^1,2, Kouhei Kamiya³, Koji Kamagata¹, Hiroshi Kusahara⁴, Masahiro Abe⁴, Shohei Fujita^1,2, Toshiaki Akashi¹, Katsuhiro Sano¹, Akihiko Wada¹, Masaaki Hori³, Osamu Abe², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan, ⁴Advanced MRI development PJ Team, Canon Medical Systems corp., Kanagawa, Japan

Cortical and subcortical gray matter (GM) are histologically different and have different DTI values. In this study, we measured the microscopic fractional anisotropy (μFA) of cortical and subcortical GM in healthy subjects using double-diffusion encoding. We confirmed that the μFA and fractional anisotropyof subcortical GM were higher than those of cortical GM. Additionally, the μFA in the globus pallidus was high than in the striatum. Myelin was higher in subcortical GM than in cortical GM, and it was higher in globus pallidus than in the striatum; therefore, higher μFA may reflect these histological features.

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