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Abstract #2150

Structural 3DT1 scans with compressed sensing are suitable for cross-sectional brain volume measures in multiple sclerosis

Jonathan Stutters1, Marco Battiston1, Nevin John1, Thomas Williams1, Claudia Wheeler-Kingshott1,2,3, Frederik Barkhof1,4,5, Jeremy Chataway1, and Ferran Prados1,4,6
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, 2Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 3Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy, 4Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London (UCL), London, United Kingdom, 5Department of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, Netherlands, 6e-Health Centre, Universitat Oberta de Catalunya, Barcelona, Spain

Optimizations of a 3D T1 sequence to take advantage of recent improvements to the hardware and software of a Philips Achieva MRI scanner allowed an acquisition to be performed in one third of the original time. We compared a number of cross-sectional volume measures, often used in research studies or as outcome measures of clinical trials, computed from images obtained with this protocol and the more widely used non-accelerated one. We find that cross-sectional volume measures are highly correlated between the accelerated and non-accelerated protocols, warranting the adoption of the accelerated one in clinical studies and clinical trials.

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