Abstract #2150

Structural 3DT1 scans with compressed sensing are suitable for cross-sectional brain volume measures in multiple sclerosis

Jonathan Stutters¹, Marco Battiston¹, Nevin John¹, Thomas Williams¹, Claudia Wheeler-Kingshott^1,2,3, Frederik Barkhof^1,4,5, Jeremy Chataway¹, and Ferran Prados^1,4,6

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, ²Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, ³Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy, ⁴Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London (UCL), London, United Kingdom, ⁵Department of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, Netherlands, ⁶e-Health Centre, Universitat Oberta de Catalunya, Barcelona, Spain

Optimizations of a 3D T1 sequence to take advantage of recent improvements to the hardware and software of a Philips Achieva MRI scanner allowed an acquisition to be performed in one third of the original time. We compared a number of cross-sectional volume measures, often used in research studies or as outcome measures of clinical trials, computed from images obtained with this protocol and the more widely used non-accelerated one. We find that cross-sectional volume measures are highly correlated between the accelerated and non-accelerated protocols, warranting the adoption of the accelerated one in clinical studies and clinical trials.

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