Abstract #2153

Atrophy Quantification in Multiple Sclerosis: Application to the Multicenter INNI Dataset

Loredana Storelli¹, Elisabetta Pagani¹, Patrizia Pantano^2,3, Nikolaos Petsas², Gioacchino Tedeschi⁴, Antonio Gallo⁴, Nicola De Stefano⁵, Marco Battaglini⁵, Paola Zaratin⁶, Maria A. Rocca^1,7,8, and Massimo Filippi^1,7,8,9,10

¹Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, ²Department of Human Neurosciences, "La Sapienza" Rome University, Rome, Italy, ³Department of Radiology, IRCCS Neuromed, Pozzilli, Italy, ⁴Department of Advanced Medical and Surgical Sciences, and 3T MRI Center, University of Campania “Luigi Vanvitelli”, Naples, Italy, ⁵Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy, ⁶Fondazione Italiana Sclerosi Multipla, Genoa, Italy, ⁷Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, ⁸Vita-Salute San Raffaele University, Milan, Italy, ⁹Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, ¹⁰Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy

Using the multicenter dataset available within the Italian Neuroimaging Network Initiative, we compared the performance of different atrophy tools on brain MRI from 457 multiple sclerosis (MS) patients and 271 healthy controls, since monitoring neurodegeneration is one of the most important goals of therapeutic strategies in MS. We found an acceptable agreement and comparable performances among the software for GM and whole brain atrophy quantification. The free licence, speed and facility of integration in the clinical routine are also important aspects to consider for the selection of the atrophy pipeline. These results should be confirmed on large-scale longitudinal data.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.