Meeting Banner
Abstract #2199

Evaluation of a spectroscopy sequence using polychromatic refocusing to suppress J-modulation and measure lactate diffusion in the rodent brain

Sophie Malaquin1, Eloïse Mougel1, Melissa Vincent1, and Julien Valette1
1Université Paris-Saclay, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Molecular Imaging Research Center (MIRCen), Laboratoire des Maladies Neurodégénératives, Fontenay aux Roses, France

Diffusion-weighted NMR spectroscopy allows non-invasive measurement of the diffusion properties of brain metabolites. Lactate is of particular interest but has low concentration thus requiring the development of new sequences to maximize signal-to-noise ratio. In this work, we compare a reference stimulated echo sequence and two spin echo sequences using either a broad pulse, or a selective polychromatic pulse suppressing J-modulation, by measuring the signal attenuation as a function of diffusion-weighting. Suppression of J-modulation with the polychromatic spin echo sequence leads to a significant signal gain and a better precision in lactate signal attenuation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here