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Abstract #2200

In Vivo J-difference Editing of (Phosphoryl)ethanolamine

Muhammad G Saleh1, Steve Hui2, Helge Zöllner2, and Richard A Edden2
1University of Maryland School of Medicine, Baltimore, MD, United States, 2The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Phosphorylethanolamine/ethanolamine (PE) serves as an important precursor for choline-containing compounds that are crucial for cell-membrane formation and maintenance. As such, PE can be influenced by pathways involving choline production in brain diseases that cause neuroinflammation. PE is also implicated in diseases that are known to cause neuronal damage. Therefore, PE may be a potential marker for investigating brain integrity. MEGA-PRESS, a spectral editing method, allows direct detection and in vivo measurement of PE. Here, we demonstrate the optimal editing of PE using MEGA-PRESS to facilitate unambiguous in vivo measurements of PE.

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