The J-refocused double spin echo sequence is applied at 7T using the 8x2 transceiver and demonstrated in the frontal-parietal and temporal lobe regions. Spectral quality parameters based on the Cramer Rao lower bound, linewidth and SNR are calculated and considered for multiplet and singlet compounds, finding that the variance in highly overlapped compounds such as myo-Inositol are more steeply dependent on spectral uncertainty compared with singlet compounds. With fast encoding methods, the J-refocused acquisition is achieved in clinically acceptable imaging times (<3min, single slice) and can detect abnormalities in Glutamine in brain tumor patients.
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