Abstract #2202

Associations of tau aggregates and oxidative stress to apathy levels in progressive supranuclear palsy

Kiwamu Matsuoka^1,2, Yuhei Takado¹, Kenji Tagai¹, Manabu Kubota³, Yasunori Sano¹, Keisuke Takahata¹, Maiko Ono¹, Chie Seki¹, Hideki Matsumoto^1,4, Hironobu Endo¹, Hitoshi Shinotoh¹, Jamie Near⁵, Kazunori Kawamura¹, Ming-Rong Zhang¹, Hitoshi Shimada¹, and Makoto Higuchi¹

¹National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²Department of Psychiatry, Nara Medical University, Kashihara, Japan, ³Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Department of Oral and Maxillofacial Radiology, Tokyo Dental College, the city of Chiyoda-ku, Japan, ⁵Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montréal, QC, Canada

Apathy is characterized by lack of motivation. We investigated the mechanisms underlying apathy in progressive supranuclear palsy (PSP), which is characterized by tau aggregate accumulations causing oxidative stress in the brain. Using magnetic resonance spectroscopy and tau positron emission tomography, we found associations of apathy levels with glutathione levels in the posterior cingulate cortex (PCC), tau aggregate accumulation levels in the angular gyrus/PCC, and atrophy of the right inferior frontal gyrus and anterior cingulate cortex. The vulnerability of the anterior and posterior brain regions where apathy is related is suggested as possible underlying mechanisms for apathy in PSP.

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