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Abstract #2202

Associations of tau aggregates and oxidative stress to apathy levels in progressive supranuclear palsy

Kiwamu Matsuoka1,2, Yuhei Takado1, Kenji Tagai1, Manabu Kubota3, Yasunori Sano1, Keisuke Takahata1, Maiko Ono1, Chie Seki1, Hideki Matsumoto1,4, Hironobu Endo1, Hitoshi Shinotoh1, Jamie Near5, Kazunori Kawamura1, Ming-Rong Zhang1, Hitoshi Shimada1, and Makoto Higuchi1
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2Department of Psychiatry, Nara Medical University, Kashihara, Japan, 3Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan, 4Department of Oral and Maxillofacial Radiology, Tokyo Dental College, the city of Chiyoda-ku, Japan, 5Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montréal, QC, Canada

Apathy is characterized by lack of motivation. We investigated the mechanisms underlying apathy in progressive supranuclear palsy (PSP), which is characterized by tau aggregate accumulations causing oxidative stress in the brain. Using magnetic resonance spectroscopy and tau positron emission tomography, we found associations of apathy levels with glutathione levels in the posterior cingulate cortex (PCC), tau aggregate accumulation levels in the angular gyrus/PCC, and atrophy of the right inferior frontal gyrus and anterior cingulate cortex. The vulnerability of the anterior and posterior brain regions where apathy is related is suggested as possible underlying mechanisms for apathy in PSP.

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