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Abstract #2203

Sleep-Wake Lactate Dynamics in Human BrainĀ 

Selda Yildiz1,2, Miranda M. Lim2,3,4,5,6, Manoj K. Sammi1,7, Katherine Powers1, Charles F. Murchison2,8, Jeffrey J. Iliff9,10,11,12,13, and William D. Rooney1,2,5,10
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Department of Neurology, Oregon Health & Science University, Portland, OR, United States, 3VA Portland Health Care System, Portland, OR, United States, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, United States, 5Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States, 6Oregon Institute of Occupational Health Sciences;, Oregon Health & Science University, Portland, OR, United States, 7BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, United States, 8Department of Biostatistics, University of Alabama, Birmingham, AL, United States, 9Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, United States, 10Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States, 11VISN 20 Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA, United States, 12Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States, 13Department of Neurology, University of Washington, Seattle, WA, United States

This study describes a non-invasive combined magnetic resonance spectroscopy and polysomnography approach to measure brain metabolite levels together with simultaneous characterization of sleep or wake states. The results provide the first in-vivo demonstration of reductions in brain lactate concentration and diffusivity during sleep versus wakefulness in young healthy human brain. These findings are consistent with invasive small-animal studies showing the loss of extracellular lactate during sleep, and support the notion of altered lactate metabolism and/or increased glymphatic activity in sleeping human brain.

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