Abstract #2203

Sleep-Wake Lactate Dynamics in Human Brain

Selda Yildiz^1,2, Miranda M. Lim^2,3,4,5,6, Manoj K. Sammi^1,7, Katherine Powers¹, Charles F. Murchison^2,8, Jeffrey J. Iliff^{9,10,11,12,13}, and William D. Rooney^1,2,5,10

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Department of Neurology, Oregon Health & Science University, Portland, OR, United States, ³VA Portland Health Care System, Portland, OR, United States, ⁴Department of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, United States, ⁵Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States, ⁶Oregon Institute of Occupational Health Sciences;, Oregon Health & Science University, Portland, OR, United States, ⁷BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR, United States, ⁸Department of Biostatistics, University of Alabama, Birmingham, AL, United States, ⁹Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, United States, ¹⁰Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States, ¹¹VISN 20 Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA, United States, ¹²Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States, ¹³Department of Neurology, University of Washington, Seattle, WA, United States

This study describes a non-invasive combined magnetic resonance spectroscopy and polysomnography approach to measure brain metabolite levels together with simultaneous characterization of sleep or wake states. The results provide the first in-vivo demonstration of reductions in brain lactate concentration and diffusivity during sleep versus wakefulness in young healthy human brain. These findings are consistent with invasive small-animal studies showing the loss of extracellular lactate during sleep, and support the notion of altered lactate metabolism and/or increased glymphatic activity in sleeping human brain.

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