Meeting Banner
Abstract #2204

Reduced fMRI activation in the fusiform face area is related to higher hallucination proneness and lower glutamate levels assessed by 1H MRS

Ralf Mekle1, Jochen B. Fiebach1, and Heiner Stuke2
1Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin, Germany

The neurophysiological and neurochemical alterations involved in the formation of hallucinations are not sufficiently understood. fMRI was used during a face detection task, and neurotransmitter levels in the visual cortex were measured by 1H MRS at 3T to elucidate processes involved in the false (hallucinatory) detection of faces in pure noise patterns. Increased hallucinatory face detections were related to decreased activation of the fusiform face area. In addition, decreased face-dependent activation was related to reduced glutamate levels. These findings substantiate theories of hallucinatory misperceptions, which implicate impaired glutamatergic transmission in a reduced ability to differentiate between meaningful information and noise.

This abstract and the presentation materials are available to members only; a login is required.

Join Here