Meeting Banner
Abstract #2210

Repeatability assessment of GABA and GSH concentrations with HERMES: a comparison between traditional analysis and a novel approach

Diana Rotaru1, Georg Oeltzschner2,3, Richard Edden2,3, and David Lythgoe1
1Neuroimaging, King's College London, London, United Kingdom, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Precise and accurate quantitation of GABA and GSH on 3T MR platforms is a great challenge in MR Spectroscopy. Despite this aspect, the reproducibility and repeatability of GABA and GSH measurements have been given little attention. In this study, test-retest repeatability was assessed for HERMES GABA and GSH estimates determined in LCModel using conventional single-spectrum analysis of Hadamard-reconstructed spectra (GABA difference, GSH difference and sum) and a novel analysis approach that models the Hadamard-reconstructed spectra simultaneously, hence using all spectral information acquired. The concatenated method allows simultaneous quantitation of GABA and GSH and provides comparable repeatability to traditional single-spectrum analysis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here