Precise and accurate quantitation of GABA and GSH on 3T MR platforms is a great challenge in MR Spectroscopy. Despite this aspect, the reproducibility and repeatability of GABA and GSH measurements have been given little attention. In this study, test-retest repeatability was assessed for HERMES GABA and GSH estimates determined in LCModel using conventional single-spectrum analysis of Hadamard-reconstructed spectra (GABA difference, GSH difference and sum) and a novel analysis approach that models the Hadamard-reconstructed spectra simultaneously, hence using all spectral information acquired. The concatenated method allows simultaneous quantitation of GABA and GSH and provides comparable repeatability to traditional single-spectrum analysis.
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