Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate by short TE 1H MRS spectra without the need for 13C channels, RF coils or scan software as required for direct 13C MRS or 13C edited 1H observed MRS. In this work, the labeling effects were followed in the frontal cortex and the occipital lobe using a short TE 1H MC-semiLASER sequence at 9.4T in healthy volunteers after oral intake of [13C-1]glucose. The spectral time series acquired show obvious 13C labelling related changes in the 1H observed Glu and Gln spectral pattern.
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