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Abstract #2214

Mapping of differential metabolic regions of RRMS patients in multi-slices dimensional using Spiral-MRSI technique

Oun Al-iedani1,2, Jeannette Lechner-Scott2,3,4, Rodney Lea2, Ovidiu Andronesi5, and Saadallah Ramadan2,6
1School of Health Sciences, University of Newcastle, Newcastle, Australia, 2Hunter Medical Research Institute, Newcastle, Australia, 3Department of Neurology, John Hunter Hospital, Newcastle, Australia, 4School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, 5Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States, 6Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia

The study designed a novel multi-dimensional metabolic mapping using multi-slice-spiral-MRSI with multi-voxel segmentation and differential metabolic regions(DMRs) techniques to demonstrate the true nature of NAWM and WM-lesions of RRMS patients,compared to HCs. 3D-spiral-MRSI covering majority of the brain in 16 RRMS and 13 HCs were used. Multi-slice-MRSI was processed using novel pipeline with DMRs classifications. Neurometabolic mapping of multi-DMRs revealed that(NAA/tCr) in WM-lesions was significantly lower than NAWM-MS and HCs,while (m-Ins/tCr) in WM-lesions were significantly higher than NAWM-MS and HCs. Multi-slice-spiral-MRSI coupled with DMRs may enhance a clinical monitoring of RRMS patients, and is sensitive in diagnosing NAWM in RRMS

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