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Abstract #2215

Metabolic Impact of Spontaneous Trigeminal Allodynia in Sprague-Dawley Rats: Implications for Migraine & other Neurological Disorders

Samuel W. Holder1,2, Michael Graham Harrington3, and Samuel Colles Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States, 3Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, United States

Spontaneous Trigeminal Allodynia (STA) occurs within ~50% of male Sprague-Dawley rats, presents symptoms analogous to migraine and may be alleviated by migraine treatments. Relaxation-enhanced MRS implemented in the female rat thalamus at 21.1 T examined metabolic effects of STA using a nitroglycerin-injected model of migraine. It was found that STA generates glutamate/glutamine and limited lactate responses with even saline injection. However, the STA response is rendered negligible when given a conventional dose of 10-mg/kg nitroglycerin. Future spectroscopic examinations of neurological disorders, particularly those focused on excitotoxicity/neuroprotection, should account for this potential effect.

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