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Abstract #2216

1H MRS biomarkers in spinocerebellar ataxia type 1

Kirsten Kapteijns1, Teije van Prooije1, Jack JA van Asten2, Bart van de Warrenburg1, and Tom WJ Scheenen2
1Dept of Neurology, Radboudumc, Nijmegen, Netherlands, 2Dept of Medical Imaging, Radboudumc, Nijmegen, Netherlands

Reliable biomarkers for SCA1 are necessary to reach trial-readiness. However, with small samples, it is important to interrogate the robustness of earlier biomarker findings. We performed single voxel 1H-MRS on 23 patients and 7 controls in the pons, cerebellar white matter, and vermis. Participants were evaluated on ataxia severity (SARA scale). Differences between groups showed alterations in tNAA, glutamate, and myo-Inositol. Negative correlations of tNAA with SARA could be found in all VOIs, and glutamate showed a negative correlation with SARA in the cerebellar WM. These findings are in line with earlier studies, and support the idea of MRS biomarkers.

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