Reliable biomarkers for SCA1 are necessary to reach trial-readiness. However, with small samples, it is important to interrogate the robustness of earlier biomarker findings. We performed single voxel 1H-MRS on 23 patients and 7 controls in the pons, cerebellar white matter, and vermis. Participants were evaluated on ataxia severity (SARA scale). Differences between groups showed alterations in tNAA, glutamate, and myo-Inositol. Negative correlations of tNAA with SARA could be found in all VOIs, and glutamate showed a negative correlation with SARA in the cerebellar WM. These findings are in line with earlier studies, and support the idea of MRS biomarkers.
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