Abstract #2217

Examining the relationship between glutathione and post-traumatic headache in patients with persistent post-concussive symptoms

Julie M Joyce^1,2,3,4, Leah J Mercier^2,4,5, Parker L La^1,2,3,4, Tiffany Bell^1,2,3, Julia M Batycky^2,4,5, Chantel T Debert^2,3,4,5, and Ashley D Harris^1,2,3,4

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁴Integrated Concussion Research Program, University of Calgary, Calgary, AB, Canada, ⁵Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

Persistent post-concussive symptoms (PPCS) are debilitating symptoms that endure beyond the usual recovery period after concussion. Post-traumatic headache is one of the most common symptoms of concussion and its pathophysiology remains poorly characterized. Oxidative stress may contribute to the symptoms seen in PPCS patients. Here, we use edited magnetic resonance spectroscopy to investigate levels of the antioxidant glutathione in the anterior cingulate and sensorimotor cortices in adults with PPCS relative to controls. In the anterior cingulate—a critical hub in the default mode network—we found a significant positive correlation between glutathione and functional impact of headache in PPCS patients.

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