Abstract #2218

1H MR spectroscopic imaging for identifying diffuse abnormalities in mild traumatic brain injury: initial results from a reproducibility study

Anna M Chen¹, Teresa Gerhalter¹, Seena Dehkharghani^1,2, Rosemary Peralta¹, Fatemeh Adlparvar¹, Martin Gajdošík³, Mickael Tordjman^1,4, Julia Zabludovsky¹, Sulaiman Sheriff⁵, James S Babb¹, Tamara Bushnik⁶, Jonathan M Silver⁷, Brian S Im⁶, Stephen P Wall⁸, Guillaume Madelin¹, and Ivan I Kirov^1,2,9

¹Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, ³Department of Biomedical Engineering, Columbia University School of Engineering and Applied Science, New York, NY, United States, ⁴Department of Radiology, Cochin Hospital, Paris, France, ⁵Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, United States, ⁶Department of Rehabilitation Medicine, New York University Grossman School of Medicine, New York, NY, United States, ⁷Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, ⁸Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, New York, NY, United States, ⁹Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

We present initial results from a reproducibility study of ¹H MRSI in mild traumatic brain injury. In line with previous investigations in a separate cohort, linear regression analysis revealed white matter differences between patients and controls, which persisted when comparing only non-recovered patients to controls. In contrast to previous findings, however, the differences were not in N-acetyl aspartate (NAA), but in the glial markers creatine (Cr), choline (Cho), and myo-inositol (mI). Correlations were found between metabolites and neuropsychological testing in grey matter (GM), and between metabolites and symptomatology in white matter (WM).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.