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Abstract #2220

Quantification of GABA in ultra-short TE 7-T human MR spectra

Guglielmo Genovese1, Dinesh K. Deelchand1, Melissa Terpstra1, and Malgorzata Marjanska1
1Center for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, MN, United States

The goal of this abstract was to deepen the knowledge on the influence of LCModel fitting parameters and SNR on GABA quantification and on the sensitivity for detecting differences in GABA levels. To this aim, GABA concentrations were quantified using different LCModel approaches and different number of averages in synthetically altered spectra generated by adding synthetic GABA signal to in-vivo ultra-short TE, 7-T human spectra.

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