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Abstract #2222

Comparison of Semi-LASER and Short-TE STEAM Pulse Sequences for Cerebral Glucose Quantification via Detecting H1-Α-Glucose Peak in 1H MRS at 7 T

Hideto Kuribayashi1, Yuta Urushibata1, Thuy Ha Duy Dinh2, Hirohiko Imai3, Sinyeob Ahn4, Ravi Teja Seethamraju5, Tadashi Isa2, and Tomohisa Okada2
1Siemens Healthcare K.K., Tokyo, Japan, 2Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Kyoto University Graduate School of Informatics, Kyoto, Japan, 4Siemens Medical Solutions, Berkeley, CA, United States, 5Siemens Medical Solutions, Boston, MA, United States

Single voxel MRS pulse sequences of semi-LASER and short-TE STEAM were compared for cerebral glucose quantification via detecting H1-α-glucose peak at 5.23 ppm. Young healthy non-fasted subjects were scanned on a whole-body 7T MRI. Spectra were analyzed on LCModel and in-house MATLAB software. Semi-LASER (32-ms TE) detected the H1-α-glucose peak at posterior cingulate cortex (27-mL volume) with higher SNR (9.1 vs 5.1) than short-TE STEAM (5-ms TE) in shorter scan time (11 vs. 12.5 minutes), respectively, and estimated glucose concentration to be 1.26 mM. More robust water suppression techniques are required to stabilize baselines around the peak.

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