Abstract #2222

Comparison of Semi-LASER and Short-TE STEAM Pulse Sequences for Cerebral Glucose Quantification via Detecting H1-Α-Glucose Peak in 1H MRS at 7 T

Hideto Kuribayashi¹, Yuta Urushibata¹, Thuy Ha Duy Dinh², Hirohiko Imai³, Sinyeob Ahn⁴, Ravi Teja Seethamraju⁵, Tadashi Isa², and Tomohisa Okada²

¹Siemens Healthcare K.K., Tokyo, Japan, ²Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Kyoto University Graduate School of Informatics, Kyoto, Japan, ⁴Siemens Medical Solutions, Berkeley, CA, United States, ⁵Siemens Medical Solutions, Boston, MA, United States

Single voxel MRS pulse sequences of semi-LASER and short-TE STEAM were compared for cerebral glucose quantification via detecting H1-α-glucose peak at 5.23 ppm. Young healthy non-fasted subjects were scanned on a whole-body 7T MRI. Spectra were analyzed on LCModel and in-house MATLAB software. Semi-LASER (32-ms TE) detected the H1-α-glucose peak at posterior cingulate cortex (27-mL volume) with higher SNR (9.1 vs 5.1) than short-TE STEAM (5-ms TE) in shorter scan time (11 vs. 12.5 minutes), respectively, and estimated glucose concentration to be 1.26 mM. More robust water suppression techniques are required to stabilize baselines around the peak.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.