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Abstract #2223

1H MRS of the Pediatric Brain Metabolism During Cardiopulmonary Bypass (CPB) Surgery

Daniel Spielman1, Phil Adamson2, Ralph Hurd1, Meng Gu1, Kirk Riemer3, Ryan Beckman3, Michael Ma3, Kenichi Okamura3, and Frank Hanley3
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States, 3Cardiothoracic Surgery, Stanford University, Stanford, CA, United States

We used single-voxel 1H MRS at 3T to study acute brain metabolic changes during cardiopulmonary bypass (CPB) surgery in a neonatal piglet model, with the overall goal of determining optimal surgical parameters for minimizing brain injury. The recent improvements in proton spectroscopy and MR scanner performance allowed robust measurement of dynamic brain water and metabolic changes during hypothermia and circulatory arrest. Key findings include a linear relationship between unsuppressed water and brain temperature, observation of the theoretically predicted NMR “powder pattern” from intravascular water during hypoxia, and quantitative measurements of glucose, lactate, and phosphocreatine metabolic rates vs temperature.

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