Abstract #2225

Exploring Brain Metabolites in Pediatric Concussion: An A-CAP Study

Parker L La¹, Robyn Walker¹, Julie M Joyce¹, Tiffany Bell¹, William Craig², Quynh Doan³, Miriam Beauchamp⁴, Roger Zemek⁵, Pediatric Emergency Research Canada (PERC)⁶, Keith O Yeates⁷, and Ashley D Harris¹

¹Radiology, University of Calgary, Calgary, AB, Canada, ²Pediatrics, University of Alberta and Stollery Children's Hospital, Edmonton, AB, Canada, ³Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Psychology, University of Montreal and St Justine Hospital, Montreal, QC, Canada, ⁵Pediatrics and Emergency Medicine, University of Ottawa and Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ⁶Alberta Children's Hospital, Calgary, AB, Canada, ⁷Psychology, University of Calgary, Calgary, AB, Canada

Disruptions in brain metabolites following concussion are commonly reported in the literature. These studies often have different timings following injury, are limited to adults and have limited sample size. Using magnetic resonance spectroscopy (MRS), we show in the largest MRS in pediatric concussion study to date, that there are no group differences in metabolites between concussion and orthopedic injury at acute injury. Glx was associated with cognitive symptoms but no other metabolites showed a relationship with symptoms. No difference between groups may indicate that metabolic disturbance following injury may be a broad indicator of injury or alterations are regionally specific.

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