Abstract #2226

Measurement of local values of cerebral pH in mild traumatic brain injury using 1H MR spectroscopy

Peter Bulanov¹, Andrei Manzhurtsev^1,2, Petr Menshchikov^3,4, Maxim Ublinskiy^2,3, Ilya Melnikov², Natalia Semenova^1,2,3,5, and Tolib Akhadov²

¹Lomonosov Moscow State University, Moscow, Russian Federation, ²Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation, ³Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation, ⁴PHilips Healthcare, Russia, Moscow, Russian Federation, ⁵Semenov Institute of Chemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation

The effect of mild traumatic brain injury (mTBI) on the values of the cerebral pH in the region of the posterior cingulate cortex was studied. pH was determined by analyzing the chemical shifts of mobile protons in the aromatic region of the spectrum of histidine, homocarnosine, resonating at ~7-8 ppm in PRESS spectra. According to our data, the pH value decreases by ~1% in posterior cingulate cortex after acute mTBI.

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