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Abstract #2226

Measurement of local values of cerebral pH in mild traumatic brain injury using 1H MR spectroscopy

Peter Bulanov1, Andrei Manzhurtsev1,2, Petr Menshchikov3,4, Maxim Ublinskiy2,3, Ilya Melnikov2, Natalia Semenova1,2,3,5, and Tolib Akhadov2
1Lomonosov Moscow State University, Moscow, Russian Federation, 2Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation, 3Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation, 4PHilips Healthcare, Russia, Moscow, Russian Federation, 5Semenov Institute of Chemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation

The effect of mild traumatic brain injury (mTBI) on the values of the cerebral pH in the region of the posterior cingulate cortex was studied. pH was determined by analyzing the chemical shifts of mobile protons in the aromatic region of the spectrum of histidine, homocarnosine, resonating at ~7-8 ppm in PRESS spectra. According to our data, the pH value decreases by ~1% in posterior cingulate cortex after acute mTBI.

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