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Abstract #2227

The Correlation of Neurometabolites on Presentation of Post-Concussion Phenotypes

Katherine Breedlove1, David R Howell2, Inga K Koerte3,4, Eduardo Coello4, Molly Charney4, Huijin Liao4, Corey Lanois5, and Alexander Lin4
1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Childrens Hospital Colorado, Aurora, CO, United States, 3Ludwig-Maximilians-Universitat, Munich, Germany, 4Brigham and Women's Hospital, Boston, MA, United States, 5Boston Children's Hospital, Boston, MA, United States

A population of collegiate athletes was evaluated post-concussion for neurometabolic levels in the PCG by magnetic resonance spectroscopy (MRS) and Post-Concussion Symptom Scale (PCSS) following injury. Evaluations were conducted within 72 hours of diagnosed concussion with a follow-up two months after injury. Correlations between neurometabolic concentration and PCSS composite scores were explored. For the purpose of this work, focus was given to the concentrations and concentration ratios of total NAA (NAA+NAAG), total Glutamate (Glu+Gln), and Glutamate (Glu). The change in metabolites between the two time points was also computed.

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