Abstract #2228

Hypoxia alters posterior cingulate cortex metabolism during a memory task: a 1H fMRS study

Matthew Rogan^1,2,3, Joseph B R Smith^1,2,3, Alexander Friend^3,4, Jamie H Macdonald^3,4, Sam J Oliver^3,4, Gabriella M K Rossetti⁵, Mark Mikkelsen^6,7, Richard A E Edden^6,7, and Paul G Mullins^1,2,3

¹School of Psychology, Bangor University, Bangor, United Kingdom, ²The Bangor Imaging Unit, Bangor University, Bangor, United Kingdom, ³The Extremes Research Group, Bangor University, Bangor, United Kingdom, ⁴School of Sport Health and Exercise Sciences, Bangor University, Bangor, United Kingdom, ⁵Centre for Integrative Neuroscience and Neurodynamics, University of Reading, Reading, United Kingdom, ⁶Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Our group has previously shown that exposure to environmental hypoxia reduces regional CBF within the posterior nodes of the default mode network. Within the same region, hypoxia also reversed the task evoked BOLD response. However, it is unclear what neurometabolic signals underlie this peculiar hemodynamic response to hypoxia. To investigate we employed event related functional MRS to measure the dynamic changes in neurometabolites within the posterior cingulate during hypoxia. We found that hypoxia negates the functional increase in glutamate as seen in normoxia, and induced a regional reduction in glucose. This observation suggests that hypoxia may reduce regional oxidative metabolism.

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