Abstract #2230

Hippocampal Single-Voxel MR Spectroscopy with Long Echo Time at 3 Tesla

Martin Gajdošík^1,2, Karl Landheer¹, Kelley M. Swanberg¹, Fatemeh Adlparvar², Guillaume Madelin², Wolfgang Bogner³, Christoph Juchem^1,4, and Ivan I. Kirov^2,5,6

¹Department of Biomedical Engineering, Columbia University, New York City, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, ³High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Department of Radiology, Columbia University Medical Center, New York City, NY, United States, ⁵Department of Neurology, New York University Grossman School of Medicine, New York City, NY, United States, ⁶Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States

The hippocampus is one of the most challenging brain regions for proton MR spectroscopy (MRS) applications. Moreover, quantification of J-coupled species such as myo-inositol (m-Ins) and glutamate + glutamine (Glx) is affected by the presence of macromolecular background. Here we investigate the feasibility of reproducibly measuring their concentrations at long T_E of 120 ms, using sLASER localization.

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