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Abstract #2231

Protective role of Creatine in chronic hepatic encephalopathy developing brain: in vivo longitudinal 1H and 31P-MRS study

Dunja Simicic1,2,3, Katarzyna Pierzchala1,2, Olivier Braissant4, Stefanita-Octavian Mitrea1,2, Dario Sessa5, Valerie McLin5, and Cristina Cudalbu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Laboratory of Fuctional and Metabolic Imaging, EPFL, Lausanne, Switzerland, 4Service of Clinical Chemistry, University of Lausanne and University Hospital of Lausanne, Lausanne, Switzerland, 5Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland

Type-C hepatic encephalopathy (CHE) is a complication of chronic liver disease (CLD). It is known that children are more affected by CLD than adult patients. Bile duct ligated rat (BDL) is a model of CLD-induced CHE. It was shown that rats having acquired CLD as pups display more profound neurometabolic disturbances than adults. Cr-treatment showed a positive effect in youngP21 BDL-rats resulting in less pronounced metabolic changes. Our aim was to test whether Cr-supplementation dampens the changes observed in CHE in a longitudinal model of CLD acquired in early childhood-P15 and if these changes are similar to those in P21-rats.

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