Abstract #2233

On the repeatability and reproducibility of SPECIAL-based in-vivo spectroscopy with different adiabatic inversion pulses

Layla Tabea Riemann¹, Christoph Stefan Aigner¹, Ralf Mekle², Sebastian Schmitter¹, Bernd Ittermann¹, and Ariane Fillmer¹

¹Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany, ²Center for Stroke Research Berlin, Charité Universitätsmedizin, Berlin, Germany

This work assesses the test-retest repeatability and reproducibility of spectral shapes and neurochemical profiles of the SPECIAL ¹H MR spectroscopy sequence employing three different adiabatic pulses in-vivo at 7T: the standard hyperbolic secant pulse and two gradient-modulated pulses, namely a GOIA and a WURST pulse. Nine healthy volunteers were scanned four times each, with all three SPECIAL variants to establish three different repeatability or reproducibility measures and to evaluate the limits in the precision of the resulting metabolite quantification.

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