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Abstract #2233

On the repeatability and reproducibility of SPECIAL-based in-vivo spectroscopy with different adiabatic inversion pulses 

Layla Tabea Riemann1, Christoph Stefan Aigner1, Ralf Mekle2, Sebastian Schmitter1, Bernd Ittermann1, and Ariane Fillmer1
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany, 2Center for Stroke Research Berlin, Charité Universitätsmedizin, Berlin, Germany

This work assesses the test-retest repeatability and reproducibility of spectral shapes and neurochemical profiles of the SPECIAL 1H MR spectroscopy sequence employing three different adiabatic pulses in-vivo at 7T: the standard hyperbolic secant pulse and two gradient-modulated pulses, namely a GOIA and a WURST pulse. Nine healthy volunteers were scanned four times each, with all three SPECIAL variants to establish three different repeatability or reproducibility measures and to evaluate the limits in the precision of the resulting metabolite quantification.

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