Abstract #2234

Polarity Dependent Modulation of the Motor Region Using tDCS: A Proton MR Spectroscopy Study

Rajakumar Nagarajan¹, Anant Shinde^2,3, Muhammed Enes Gunduz^2,3, and Gottfried Schlaug^2,3

¹Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, United States, ²Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, United States, ³Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, United States

We studied the effects of motor region tDCS on metabolite levels in a spectroscopic voxel with repeated episodes of 5min of constant current dose levels anticipating stimulation-induced alterations in metabolite concentration at rest. The cumulative change in GABA from before the first tDCS stimulation epoch to after the last epoch showed a significant polarity effect. The first tDCS epoch revealed polarity dependent opposite trends in GABA and Glx from baseline (before stimulation) to post-stimulation. This study provides insights into how tDCS leads to polarity dependent modulation of cerebral metabolites and might provide a model for future MRS stimulation studies.

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