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Abstract #2234

Polarity Dependent Modulation of the Motor Region Using tDCS: A Proton MR Spectroscopy Study

Rajakumar Nagarajan1, Anant Shinde2,3, Muhammed Enes Gunduz2,3, and Gottfried Schlaug2,3
1Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, United States, 2Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, United States, 3Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, United States

We studied the effects of motor region tDCS on metabolite levels in a spectroscopic voxel with repeated episodes of 5min of constant current dose levels anticipating stimulation-induced alterations in metabolite concentration at rest. The cumulative change in GABA from before the first tDCS stimulation epoch to after the last epoch showed a significant polarity effect. The first tDCS epoch revealed polarity dependent opposite trends in GABA and Glx from baseline (before stimulation) to post-stimulation. This study provides insights into how tDCS leads to polarity dependent modulation of cerebral metabolites and might provide a model for future MRS stimulation studies.

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