Abstract #2235

A time course of the glutamate+glutamine level in response to a short visual stimulus

Alexey Yakovlev^1,2,3, Andrei Manzhurtsev^1,3, Petr Menshchikov^3,4, Maxim Ublinskiy³, Tolib Akhadov¹, and Natalia Semenova^1,2,3

¹Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, ²N.N.Semenov Federal research center of Chemical Physics Russian Academy of Sciences, Moscow, Russian Federation, ³N.M. Emanuel Institute of Biochemical Physics RAS, Moscow, Russian Federation, ⁴Philips Healthcare, Moscow, Russian Federation

Changes in the concentration of neurotransmitters in response to a short (or event-related) stimulus in not well investigated. Due to low neurotransmitter cycle rates, these changes can be related to neurotransmitter release from vesicles. In this work, we measured a time course of Glx level in response to a short visual stimulus in a period exceeding the BOLD response using 3T MR scanner. This Glx level dynamic is considered as the release of Glu from the vesicles, reuptake, and refilling. For the first time, we investigated the dynamics of the BOLD-effect using the metabolic signal.

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