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Abstract #2236

Ultra-high field MR spectroscopic imaging at 7 Tesla in Multiple Sclerosis: myo-Inositol as early biomarker for MS pathologies

Alexandra Lipka1,2, Eva Heckova1, Assunta Dal-Bianco3, Gilbert Hangel1, Bernhard Strasser1, Stanislav Motyka1, Lukas Hingerl1, Paulus Rommer3, Fritz Leutmezer3, Petra Hnilicov√°4, Ema Kantorov√°4, Stephan Gruber1, Siegfried Trattnig1,2, and Wolfgang Bogner1,2
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Neurology, Medical University of Vienna, Vienna, Austria, 4Jessenius Faculty of Medicine in Martin, Comenius University, Bratislava, Slovakia

Routine T1/T2-weighted magnetic resonance imaging (MRI) is the method of choice for diagnosis and treatment monitoring of Multiple Sclerosis (MS), but is not being able to map the underlying pathological processes. In contrast to T1/T2-lesions which represent the general macroscopic tissue damage, MR Spectroscopic Imaging (MRSI) can detect pathologies on a biochemical level. In 54 relapsing-remitting (RRMS) patients and 16 healthy age/sex-matched controls, we show - enabled through ultra-high resolution Free Induction Decay(FID)-MRSI at 7T - the metabolic distribution within lesions and their close proximity as well as the importance of myo-Inositol as an imaging biomarker in early lesion development.

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