Abstract #2237

Ultra-high field MR spectroscopic imaging at 7 Tesla in Multiple Sclerosis: metabolic fingerprinting of iron rim lesions

Alexandra Lipka^1,2, Wolfgang Bogner^1,2, Assunta Dal-Bianco³, Gilbert Hangel¹, Bernhard Strasser¹, Stanislav Motyka¹, Lukas Hingerl¹, Paulus Rommer³, Fritz Leutmezer³, Stephan Gruber¹, Siegfried Trattnig^1,2, and Eva Heckova¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Department of Neurology, Medical University of Vienna, Vienna, Austria

Conventional T1/T2-weighted magnetic resonance imaging (MRI) is the method of choice for diagnosis and treatment monitoring of Multiple Sclerosis (MS). Susceptibility weighted imaging (SWI) provides additional information about iron deposition. In addition to these imaging modalities, MR Spectroscopic Imaging (MRSI) can detect pathologies on a biochemical level. In 32 relapsing remitting (RRMS) patients, we showed - with ultra-high spatial resolution Free Induction Decay(FID)-MRSI at 7T - the metabolic changes associated with different types of iron accumulation and the metabolic gradient spanning from within the lesion to its close proximity.

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