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Abstract #2243

Optimizing Brain Injury Biomarkers in a piglet model of Neonatal Encephalopathy: combining perfusion with proton MRS

Hillary Idogwu1, Magdalena Sokolska2, Pang Raymand 3, Saiful Islam4, Christopher Meehan 3, Adnan Avdic-Belltheus 3, Kathryn Marinello 3, Ingran Lingam 3, Tatenda Mutshiya 3, Alan Bainbridge 2, Nikki Robertson 3, David Thomas1, and Xavier Golay1
1Brain Repair and Rehabilitation, Institute of Neurology, UCL Queen Square Institute of Neurology, London, United Kingdom, 2Medical Physics and Biomedical Engineering, UCLH NHS Foundation Trust, London, United Kingdom, 3Neonatology, UCL EGA Institute for Women's Health, London, United Kingdom, 4UCL Queen Square Institute of Neurology, London, United Kingdom

Despite therapeutic hypothermia, some survivors of neonatal encephalopathy (NE) still have adverse outcomes. Surrogate outcome measures or biomarkers are needed for early detection of babies with adverse outcome so that adjunct therapies can be considered. Basal ganglia and thalamus (BGT) lactate/ N-Acetyl-Aspartate (Lac/NAA) peak area ratio acquired with proton magnetic resonance spectroscopy (MRS) is a reliable predictor of developmental outcome at two years. Cerebral blood flow (CBF) changes in parallel with the metabolic changes after hypoxia ischaemia (HI). We hypothesised that the combination of CBF with BGT Lac/NAA would be more closely associated with quantitative cell death than either alone.

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