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Abstract #2244

Brain asymmetry and development of healthy preterm infants within half-year-old: a diffusion MRI study based on ROI and fixel methods

Tingting Liu1, Weihao Zheng1, Yuqing You2, Ying Lv2, Weijun Chen2, Zhiyong Zhao1, Fusheng Gao2, Hongxi Zhang2, Chai Ji2, and Dan Wu1
1ZheJiang University, Hangzhou, China, 2Children's Hospital, ZheJiang University School of Medicine, Hangzhou, China

The present study aimed to investigate brain asymmetry of healthy preterm-born infants within half-year-old using high angular resolution diffusion MRI. ROI-based analysis revealed most brain regions showed significant asymmetry and the asymmetry changed with brain development. The MD-based lateralization index showed an center-versus-peripheral pattern with remarkable lateralization in the posterior cortex. Moreover, in contrast to the adult brain, we found a rightward asymmetry in language processing regions and leftward asymmetry in visuospatial processing regions. Besides, consistent leftward lateralization in white matter was observed at both ROI-based and fixel-based analysis. These findings advanced our understanding of brain asymmetry during early development.

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