We leverage an exemplar relationship (FAWM vs. postmenstrual age [PMA]) to quantify the benefits conferred by adjustment for QC measures in a multi-site infant DWI study. Data was preprocessed using a common pipeline (dHCP) and the FAWM-PMA association tested without and with controlling for SNR, CNR and mean FD. All three QC measures were broadly associated with FAWM within sites. Within and across sites, inclusion of QC measures greatly increased FAWM variance explained by PMA. Accounting for QC measures results in an improved capability for identifying reproducible small-effect size relationships in large multi-site infant imaging studies.
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