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Abstract #2245

Accounting for Measurement Noise in a Multi-Site Newborn Diffusion Weighted Imaging Study

Jerod M Rasmussen1, Alice M Graham2, Pathik D Wadhwa1, Sonja Entringer3, Martin Styner4, Beatriz Luna5, Thomas G O'Connor6, Damien A Fair7, and Claudia Buss3
1UC Irvine, Irvine, CA, United States, 2Oregon Health Sciences University, Portland, OR, United States, 3Charité – Universitätsmedizin Berlin, Berlin, Germany, 4University of North Carolina, Chapel Hill, NC, United States, 5University of Pittsburgh, Pittsburgh, PA, United States, 6University of Rochester, Rochester, NY, United States, 7University of Minnesota, Minneapolis, MN, United States

We leverage an exemplar relationship (FAWM vs. postmenstrual age [PMA]) to quantify the benefits conferred by adjustment for QC measures in a multi-site infant DWI study. Data was preprocessed using a common pipeline (dHCP) and the FAWM-PMA association tested without and with controlling for SNR, CNR and mean FD. All three QC measures were broadly associated with FAWM within sites. Within and across sites, inclusion of QC measures greatly increased FAWM variance explained by PMA. Accounting for QC measures results in an improved capability for identifying reproducible small-effect size relationships in large multi-site infant imaging studies.

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