Abstract #2246

High resolution diffusion imaging in the unfixed post-mortem neonatal brain

Wenchuan Wu¹, Luke Baxter^1,2, Eleri Adams^2,3, Foteini Andritsou², Matteo Bastiani^1,4,5, Ria Evans Fry², Robert Frost^6,7, Sean Foxley⁸, Chris Gallagher¹, Fiona Moultrie², Vaneesha Monk², David Andrew Porter⁹, Anthony Price^10,11, Sebastian W Rieger^1,12, Michael Sanders¹, Anthony David Edwards¹¹, Joseph V Hajnal^10,11, Rebeccah Slater*^1,2, and Karla L Miller*¹

¹Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Department of Paediatrics, University of Oxford, Oxford, United Kingdom, ³Newborn Care Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, ⁴Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁵NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, ⁶Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁷Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁸Department of Radiology, University of Chicago, Chicago, IL, United States, ⁹Imaging Centre of Excellence, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom, ¹⁰Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, United Kingdom, ¹¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, United Kingdom, ¹²Department of Psychiatry, University of Oxford, Oxford, United Kingdom

In this work, we develop a 7T experimental platform to acquire high resolution diffusion MRI images in unfixed post-mortem infant brains. Here we present results from a first infant. The post-mortem structural images demonstrate superior SNR and improved depiction of small structures than age-matched low-resolution in vivo data. The post-mortem diffusion MRI images show sufficient SNR to support the considerably smaller voxel volume compared to in vivo. The high spatial resolution of the post-mortem data enables the depiction of brain features (e.g., cortical radiality, subplate organization) that are less prominent in low-resolution in vivo data.

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