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Abstract #2269

3D Liver T1 Quantification using Interleaved Look-Locker Acquisition with T2 Preparation Pulse Sequence (3D-QALAS): Comparison with 2D-MOLLI

Deep B. Gandhi1, Amol Pednekar1, Hui Wang2, Jean A. Tkach1, Andrew T. Trout1, and Jonathan R. Dillman1
1Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2MR Clinical Science, Philips, Cincinnati, OH, United States

Hepatic T1 relaxation values have been shown to correlate with hepatic fibrosis. The established 2D T1 mapping techniques require multiple breath-holds to quantify whole liver T1. 3D whole liver T1 quantification in a single breath-hold using an interleaved Look-Locker acquisition sequence with T2 preparation pulse (3D-QALAS) correlates very strongly (r=0.95) with T1 values obtained with a 2D Modified Look-Locker Acquisition (2D-MOLLI). However, 3D-QALAS underestimated T1 significantly (p<0.0001) compared to 2D-MOLLI with a mean bias of 92.5 ms (14.2%). 3D-QALAS has potential to measure T1 of the whole liver in a single breath hold, while simultaneously providing T2 relaxation values.

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