Pediatric patients may experience inaccurate estimates of glomerular filtration rate (GFR) by serum creatinine or cystatin C. Renal blood flow (RBF) is a key physiological determinant of GFR, thus, phase-contrast MRI (PC-MRI) is a promising non-invasive technique to investigate relationships to GFR. An interim prospective analysis (n=18) is presented, which investigates RBF as measured by PC-MRI in pediatric bone-marrow transplant candidates who also underwent gold standard measurement of GFR by 125I iothalamate clearance (GFR-iothalamate). The correlation between GFR-iothalamate and RBF by PC-MRI was markedly superior to that of the commonly used endogenous filtration markers serum creatinine or cystatin C.
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