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Abstract #2275

Estimation of Glomerular Filtration Rate in a Pediatric Population using Renal Phase Contrast MRI

Alex J Barker1, Lorna P Browne1, Michal Schafer2, Erin K Englund2, Takashi Fujiwara2, Kristen J Nadeau2, and Petter Bjornstad2
1Radiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States, 2University of Colorado, Anschutz Medical Campus, Aurora, CO, United States

Pediatric patients may experience inaccurate estimates of glomerular filtration rate (GFR) by serum creatinine or cystatin C. Renal blood flow (RBF) is a key physiological determinant of GFR, thus, phase-contrast MRI (PC-MRI) is a promising non-invasive technique to investigate relationships to GFR. An interim prospective analysis (n=18) is presented, which investigates RBF as measured by PC-MRI in pediatric bone-marrow transplant candidates who also underwent gold standard measurement of GFR by 125I iothalamate clearance (GFR-iothalamate). The correlation between GFR-iothalamate and RBF by PC-MRI was markedly superior to that of the commonly used endogenous filtration markers serum creatinine or cystatin C.

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