Abstract #2318

The reduction in the contribution of a fast diffusing component for pancreatic malignancy detection – A preliminary study

Debbie Anaby¹, Maria Raitses-Gurevich², Sara Apter^1,3, Yael Inbar^1,3, Hadassa Degani⁴, and Talia Golan^2,3

¹Diagnostic Imaging Department, Sheba Medical Center, Ramat Gan, Israel, ²Department of Oncology, Sheba Medical Center, Ramat Gan, Israel, ³Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁴Life Sciences, Weizmann Institute of Science, Rehovot, Israel

Early detection of pancreatic cancer is challenging but essential to improve its poor prognosis. This preliminary study utilized DT-MRI in pancreas in a clinical setting. DT-MRI was based on two pairs of b-values (0,500 s/mm² and 100,500 s/mm²), such that the existence of a fast diffusing component was observed. We found that pancreatic tumors show similar values of parametric DTI measures (λ₁ and MD-ADC) when using both b-value pairs, suggesting that the fast diffusing component is reduced compared with healthy or cystic pancreatic regions. We conclude that DT-MRI of the pancreas may assist in the detection of pancreatic tumors.

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