Early detection of pancreatic cancer is challenging but essential to improve its poor prognosis. This preliminary study utilized DT-MRI in pancreas in a clinical setting. DT-MRI was based on two pairs of b-values (0,500 s/mm2 and 100,500 s/mm2), such that the existence of a fast diffusing component was observed. We found that pancreatic tumors show similar values of parametric DTI measures (λ1 and MD-ADC) when using both b-value pairs, suggesting that the fast diffusing component is reduced compared with healthy or cystic pancreatic regions. We conclude that DT-MRI of the pancreas may assist in the detection of pancreatic tumors.