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Abstract #2318

The reduction in the contribution of a fast diffusing component for pancreatic malignancy detection – A preliminary study

Debbie Anaby1, Maria Raitses-Gurevich2, Sara Apter1,3, Yael Inbar1,3, Hadassa Degani4, and Talia Golan2,3
1Diagnostic Imaging Department, Sheba Medical Center, Ramat Gan, Israel, 2Department of Oncology, Sheba Medical Center, Ramat Gan, Israel, 3Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, 4Life Sciences, Weizmann Institute of Science, Rehovot, Israel

Early detection of pancreatic cancer is challenging but essential to improve its poor prognosis. This preliminary study utilized DT-MRI in pancreas in a clinical setting. DT-MRI was based on two pairs of b-values (0,500 s/mm2 and 100,500 s/mm2), such that the existence of a fast diffusing component was observed. We found that pancreatic tumors show similar values of parametric DTI measures (λ1 and MD-ADC) when using both b-value pairs, suggesting that the fast diffusing component is reduced compared with healthy or cystic pancreatic regions. We conclude that DT-MRI of the pancreas may assist in the detection of pancreatic tumors.

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