This study explored the feasibility of evaluating fibrosis of patients with PDAC and correlate it with histopathological features using IVIM-DWI compared with DWI. No statistically significant differences were found in ADC and D* values between the high- and low-fibrosis groups. A significant negative correlation between D values and fibrosis and a significant positive correlation between f values and fibrosis were observed. D and ƒ values derived from the IVIM model had high sensitivity and diagnostic performance for grading fibrosis in PDAC compared with the conventional DWI model. IVIM-DWI could serve as an imaging biomarker for predicting the fibrosis grade of PDAC.