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Abstract #2319

Predicting fibrosis grades of pancreatic ductal adenocarcinoma using intravoxel incoherent motion diffusion-weighted imaging

Qi Liu1, Wei Xing1, Jilei Zhang2, JingGang Zhang1, Jie Chen1, and Bei Li1
1Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China, 2Clinical Science, Philips Healthcare, Shanghai, China

This study explored the feasibility of evaluating fibrosis of patients with PDAC and correlate it with histopathological features using IVIM-DWI compared with DWI. No statistically significant differences were found in ADC and D* values between the high- and low-fibrosis groups. A significant negative correlation between D values and fibrosis and a significant positive correlation between f values and fibrosis were observed. D and ƒ values derived from the IVIM model had high sensitivity and diagnostic performance for grading fibrosis in PDAC compared with the conventional DWI model. IVIM-DWI could serve as an imaging biomarker for predicting the fibrosis grade of PDAC.

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